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Glixx Laboratorie
CAS: 328998-25-0
Chemical Name: 4E1RCat; 4-[(3E)-3-[[5-(4-nitrophenyl)furan-2-yl]methylidene]-2-oxo-5-phenylpyrrol-1-yl]benzoic acid
Cat No: GLXC-02289
Purity: > 98% (HPLC)
Storage: Refrigerator (4 °C)
Novel inhibitor of eukaryotic translation initiation; Novel cap-dependent translation inhibitor, preventing eIF4F formation, blocking the ATG5-ATG16L1 and ATG5-TECAIR interactions in the in vitro binding assay (IC50 = 1-2 μM) and also exhibiting autophagy inhibition in cellular assays
References:
https://pubs.acs.org/doi/10.1021/acs.jmedchem.2c01233
https://pubmed.ncbi.nlm.nih.gov/?term=4E1RCat&sort=date
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