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USP1 inhibitor 38-P2

 

CAS: N/A

 

Chemical Name: (R)-2-(4-Cyclopropyl-6-methoxypyrimidin-5-yl)-4-(3-(4-(1-isopropyl-4-(trifluoromethyl)-1H-imidazol-2-yl)phenyl)morpholino)furo[3,2-d]pyrimidine

 

 
GLXC-07154For Lab R&D Uses Only
        Cat No: GLXC-07154

 

Purity:               >98% (HPLC)

Storage:             Refrigerator (4 °C)

 

 

Product Description:

Novel, selective, reversible, and noncompetitive USP1 inhibitor, efficiently activating the DDR pathway, inducing cell cycle arrest and cell apoptosis, and inhibiting cell survival, enhancing the sensitivity of olaparib-resistant cells to olaparib and showing a synergetic effect with andrographolide in BRCA-proficient cancer cells

 

Reference:

https://pubs.acs.org/doi/10.1021/acs.jmedchem.4c02792

 

Analytical data click for PDF file

 

 

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