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CAS: N/A
Chemical Name: (R)-2-(4-Cyclopropyl-6-methoxypyrimidin-5-yl)-4-(3-(4-(1-isopropyl-4-(trifluoromethyl)-1H-imidazol-2-yl)phenyl)morpholino)furo[3,2-d]pyrimidine
For Lab R&D Uses Only
Purity: >98% (HPLC)
Novel, selective, reversible, and noncompetitive USP1 inhibitor, efficiently activating the DDR pathway, inducing cell cycle arrest and cell apoptosis, and inhibiting cell survival, enhancing the sensitivity of olaparib-resistant cells to olaparib and showing a synergetic effect with andrographolide in BRCA-proficient cancer cells
Reference:
https://pubs.acs.org/doi/10.1021/acs.jmedchem.4c02792
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