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Glixx Laboratorie
CAS: 2962103-54-2
Chemical Name: (5-(3-(3,5-Dichlorophenyl)isoxazol-5-yl)-3-hydroxypicolinoyl)glycine
For Lab R&D Uses Only
Purity: >98% (HPLC)
Novel, potent, and selective FIH inhibitor (Ki = 79.6 nM) for treatment of obesity and fatty liver disease, occupying both the FIH catalytic site and a recently defined tyrosine conformational-flip pocket and manifesting 38-fold selectivity over the hypoxia-inducible factor (HIF) prolyl hydroxylase PHD2
Reference:
https://pubs.acs.org/doi/10.1021/acs.jmedchem.4c01698
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