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CAS: N/A
Chemical Name: N-Hydroxy-4-((2-methyl-5-oxoimidazo[1,2-c]quinazolin-6(5H)-yl)methyl)benzamide
For Lab R&D Uses Only
Purity: >98% (HPLC)
Novel potent HDAC6 inhibitor (IC50, 3.5 nM), significantly decreasing HDAC6 protein expression, disrupting microtubule organization, also increasing the phosphorylation of CDC20, BUB1, and BUBR1, indicating the activation of the spindle assembly checkpoint (SAC)
Reference:
https://onlinelibrary.wiley.com/doi/10.1002/pros.24678
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