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CAS: N/A
Chemical Name: 2-((1H-Pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((6-acrylamido-1-(4-chloro-2-ethylphenyl)-3,4-dihydronaphthalen-2-yl)methyl)piperazin-1-yl)benzoic acid
For Lab R&D Uses Only
Purity: >98% (HPLC)
Novel potent and selective BFL-1 inhibitor, inhibiting the BFL-1/BID interaction with a Ki value of 105 nM, targeting the Cys55 of BFL-1, overcaming venetoclax resistance in isogenic AML cell lines MOLM-13-OE and MV4-11-OE
Reference:
https://pubs.acs.org/doi/10.1021/acs.jmedchem.4c00291
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