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CAS: N/A
Chemical Name: (5R,7R,8S)-2,11-Bis((ethylthio)methyl)-7-hydroxy-N-((S)-13-((2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidine-1-carbonyl)-14,14-dimethyl-11-oxo-3,6,9-trioxa-12-azapentadecyl)-8-methyl-15-oxo-5,6,7,8,14,15-hexahydro-13H-16-oxa-4b,8a,14-triaza-5,8-methanodibenzo[b,h]cycloocta[jkl]cyclopenta[e]-as-indacene-7-carboxamide
For Lab R&D Uses Only
Purity: >98% (HPLC)
Novel selective MLK3 degrader, robustly degrading MLK3 and inhibiting its oncogenic activity in TNBC, reducing clonogenic and migratory potential, cell cycle arrest, and apoptosis in MDA-MB-468 cells
Reference:
https://pubs.acs.org/doi/10.1021/acs.jmedchem.4c00577
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