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CAS: N/A
Chemical Name: (R)-3-((4-(4-Bromobenzyl)-8-methyl-5-oxo-1,2,4,5,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-7(6H)-yl)methyl)benzonitrile
For Lab R&D Uses Only
Purity: >98% (HPLC)
Novel Exceptionally Potent and Orally Efficacious Human ClpP Activator (EC50 = 23.5 nM, 107.1-fold stronger than ONC201) with Strong In Vivo Antitumor Activity (inhibition of the proliferation of HL60 cells with IC50 = 4.6 nM, 169.2-fold stronger than ONC201)
Reference:
https://pubs.acs.org/doi/10.1021/acs.jmedchem.4c01605
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