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Glixx Laboratorie
CAS: 2540881-21-6
Chemical Name: 3-(3-Hydroxyphenyl)-1-methyl-7-[3-(4-methylpiperazin-1-yl)anilino]-1,6-naphthyridin-2-one
For Lab R&D Uses Only
Purity: >98% (HPLC)
Novel potent and selective RIPK3 inhibitor with an IC50 value of 20 nM, selectively blocking IAV-triggered necroptosis in alveolar epithelial cells in vivo, ameliorating lung inflammation and preventing mortality following infection with laboratory-adapted and pandemic strains of IAV, without compromising antiviral adaptive immune responses or impeding viral clearance
Reference:
https://www.nature.com/articles/s41586-024-07265-8
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