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Glixx Laboratorie
CAS: 2669785-77-5
Chemical Name: (2S,4R)-1-((S)-2-(2-((9-(2-((4-((2-Aminophenyl)carbamoyl)phenyl)amino)-2-oxoethoxy)nonyl)oxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
For Lab R&D Uses Only
Purity: >98% (HPLC)
Novel selective degrader (PROTAC) and inhibitor of class I HDACs (DC50 values are 530 nM for HDAC3 and 550 nM for HDAC1; Dmax is 77%, 66% and 45% at HDAC1, 3 and 2; IC50 values are 380 nM, 570 nM and 820 nM at HDAC3, 1 and 2)
Reference:
https://pubs.acs.org/doi/10.1021/acs.jmedchem.1c02179
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