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CAS: N/A
Chemical Name: 6-(4-(8-((3-Cyano-4-(6-(6-((6-methoxypyridin-3-yl)methyl)-3,6-diazabicyclo[3.1.1]heptan-3-yl)pyridin-3-yl)pyrazolo[1,5-a]pyridin-6-yl)oxy)octanoyl)piperazin-1-yl)-N-(2-(4-(2,6-dioxopiperidin-3-yl)phenoxy)ethyl)nicotinamide
For Lab R&D Uses Only
Purity: >98% (HPLC)
Novel selective inhibitor and degrader of RET kinase, exhibiting dual action of selectively inhibiting and depleting RET protein both in vitro and in vivo, inhibiting KIF5B-RET-driven xenograft tumors in animals
Reference:
https://pubs.acs.org/doi/10.1021/acs.jmedchem.4c01424
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