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CAS: N/A
Chemical Name: XJZ-06-462; (S)-2-(4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-1-(4-((1-(2-(4-((2-(3-((4-(dimethylphosphoryl)phenyl)amino)prop-1-yn-1-yl)-1-(2,2,2-trifluoroethyl)-1H-indol-4-yl)amino)piperidin-1-yl)acetyl)piperidin-4-yl)methyl)piperazin-1-yl)ethan-1-one
For Lab R&D Uses Only
Purity: >98% (HPLC)
Novel mutant-specific p53Y220C activator, potently activating mutant p53 and triggering robust p53 target gene transcription, upregulating p21 and other p53 target genes and inhibiting growth of p53Y220C-expressing cell lines
Reference:
https://pmc.ncbi.nlm.nih.gov/articles/PMC11565735/
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