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PD-L1/PARP7 inhibitor B3

 

CAS: N/A

 

Chemical Name: N-(2-(2-(2-((S)-1-(2,6-Dimethoxy-4-((2-methyl-[1,1'-biphenyl]-3-yl)methoxy)benzyl)piperidine-2-carboxamido)ethoxy)ethoxy)ethyl)-2-(4-(3-((S)-2-((6-oxo-5-(trifluoromethyl)-1,6-dihydropyridazin-4-yl)amino)propoxy)propanoyl)piperazin-1-yl)pyrimidine-5-carboxamide

 

 
GLXC-28699For Lab R&D Uses Only
        Cat No: GLXC-28699

 

Purity:               >98% (HPLC)

Storage:             Refrigerator (4 °C)

 

 

Product Description:

Novel dual PD-L1/PARP7 inhibitor, showing potent activity against PD-1/PD-L1 interaction (IC50 = 0.426 μM) and PARP7 (IC50 = 2.50 nM), restoring T-cell function, leading to the increase of IFN-γ secretion, displaying significant in vivo antitumor efficacy in a melanoma B16-F10 tumor mouse model

 

Reference:

https://pubs.acs.org/doi/10.1021/acs.jmedchem.4c00296


Analytical data click for PDF file

 

 

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