Glixx Laboratories Inc

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Glixx Laboratorie

 

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CIB-L43

 

CAS: 1082942-70-8

 

Chemical Name: 4-Methyl-2-(4-morpholinophenyl)thiazole-5-carboxylic acid

 

 
GLXC-29258For Lab R&D Uses Only
        Cat No: GLXC-29258

 

Purity:               >98% (HPLC)

Storage:             Refrigerator (4 °C)

 

 

Product Description:

Novel potent Transactivation response RNA-binding protein 2 (TRBP) inhibitor, demonstrating superior TRBP binding affinity (KD = 4.78 nM) and enhanced disruption of TRBP-Dicer interactions (IC50 = 2.34 μM), suppressing oncogenic miR-21 biosynthesis, increasing PTEN and Smad7 expression and inhibiting AKT and TGF-β signaling, thereby reducing HCC cell proliferation and migration

 

Reference:

https://pubs.acs.org/doi/10.1021/acs.jmedchem.4c02041

 

Analytical data click for PDF file

 

 

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