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Glixx Laboratorie
CAS: 1082942-70-8
Chemical Name: 4-Methyl-2-(4-morpholinophenyl)thiazole-5-carboxylic acid
For Lab R&D Uses Only
Purity: >98% (HPLC)
Novel potent Transactivation response RNA-binding protein 2 (TRBP) inhibitor, demonstrating superior TRBP binding affinity (KD = 4.78 nM) and enhanced disruption of TRBP-Dicer interactions (IC50 = 2.34 μM), suppressing oncogenic miR-21 biosynthesis, increasing PTEN and Smad7 expression and inhibiting AKT and TGF-β signaling, thereby reducing HCC cell proliferation and migration
Reference:
https://pubs.acs.org/doi/10.1021/acs.jmedchem.4c02041
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