Glixx Laboratories Inc
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Glixx Laboratorie
CAS: 2191110-79-7
Chemical Name: 1-(7-Benzyl-2,7-diazaspiro[4.4]nonan-2-yl)prop-2-en-1-one
For Lab R&D Uses Only
Purity: >98% (HPLC)
Novel covalent 14-3-3 PPI molecular glue, targeting both C38 and C96 on 14-3-3 to enhance 14-3-3 interactions with ERα, YAP, and TAZ, leading to impaired estrogen receptor and Hippo pathway transcriptional activity
References:
https://pubs.acs.org/doi/10.1021/jacs.3c12389
https://www.biorxiv.org/content/10.1101/2023.11.06.565850v1.full
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