Glixx Laboratories Inc
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Glixx Laboratorie
CAS: 2621401-41-8
Chemical Name: 5-(2,4-Difluoro-3-((3-((4-fluorophenyl)carbamoyl)-1H-pyrazol-4-yl)carbamoyl)phenyl)picolinamide
For Lab R&D Uses Only
Purity: >98% (HPLC)
Novel potent CDK2 inhibitor with above 10-fold selectivity against CDK2 over CDK1/4/6/7/9/12, displaying anti-proliferative activity against two cancer cell lines and low toxicity on human normal cell lines, inhibiting CDK2-medieated phosphorylation of Rb, blocking cell cycle progression and inducing apoptosis
Reference:
https://www.sciencedirect.com/science/article/abs/pii/S0223523421001306
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