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Glixx Laboratorie
CAS: 2746406-36-8
Chemical Name: 5-[4-(7-Chloro-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-2,2,6,6-tetradeuteriopiperidin-1-yl]sulfonyl-2-methyl-1,3-oxazole
For Lab R&D Uses Only
Purity: >98% (HPLC)
Novel antagonist tool compound of the M5 muscarinic acetylcholine receptor, showing exquisite potency (human M5 IC50 = 20 nM), good subtype selectivity (>500 fold selectivity against human M1-4), desirable brain exposure (Kp = 0.68, Kp,uu = 0.65), and high oral bioavailability (%F > 100%)
Reference:
https://pubs.acs.org/doi/10.1021/acs.jmedchem.4c01193
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