Glixx Laboratories Inc
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Glixx Laboratorie
CAS: 3040298-34-5
Chemical Name: (S)-5-(4-((1-(2-Hydroxyethyl)piperidin-3-yl)amino)-5,6,7,8-tetrahydro-5,8-ethanophthalazin-1-yl)benzofuran-4-ol
For Lab R&D Uses Only
Purity: >98% (HPLC)
Novel potent, specific, and orally available NLRP3 inflammasome inhibitor, exhibiting significant inhibitory effects against nigericin-induced IL-1β release in THP-1 cells, BMDMs, and PBMCs, with IC50 values of 2.7, 15.3, and 2.9 nM, respectively
Reference:
https://pubs.acs.org/doi/10.1021/acs.jmedchem.4c01341
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