Glixx Laboratories Inc
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Glixx Laboratorie
CAS: 2758436-98-3
Chemical Name: 1',4'-Diphenyl-7'-(thiophen-3-yl)spiro[cyclohexane-1,5'-pyrrolo[3,4-d]pyridazine]
For Lab R&D Uses Only
Purity: >98% (HPLC)
Novel anticancer agent, potently inducing apoptotic cell death in MCF-7, H69AR, and PC-3 cancer cells, demonstrating selective cytotoxicity against cancer cells with a low impact on nontumorigenic cells (IC50 value: 26.8 ± 0.4 μM), inhibiting antiapoptotic Bcl-2 while inducing pro-apoptotic Bax and cytochrome c, exhibiting significant EGFR kinase inhibitory activity
Reference:
https://pubs.acs.org/doi/10.1021/acsomega.4c00794
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