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CAS: N/A
Chemical Name: NSC-795332; 4-(4-(3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido)-5-(4-methoxyphenyl)-1H-pyrazol-1-yl)benzenesulfonamide
For Lab R&D Uses Only
Purity: >98% (HPLC)
Novel hCA-IX/XII inhibitor (Ki = 15.9 nM for hCA IX and Ki = 55.2 nM for hCA XII), exhibiting broad-spectrum activity with an effective growth inhibition full panel GI50 (MG-MID) value of 3.5 μM and a subpanel GI50 (MG-MID) range of 2.4-6.3 μM, enhancing the efficacy of Taxol and 5-fluorouracil in cotreatment regimens under hypoxic conditions in HCT-116 colorectal cancer cells
Reference:
https://pubs.acs.org/doi/10.1021/acs.jmedchem.4c01894
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