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FLT3 inhibitor 17




Chemical Name: (Z)-2-(Cyclopentylamino)-N-(5-((5-fluoro-2-oxoindolin-3-ylidene)methyl)-4-methyl-1H-pyrrol-3-yl)acetamide


GLXC-23897For Lab R&D Uses Only
        Cat No: GLXC-23897


Purity:               >98% (HPLC)

Storage:             Refrigerator (4 °C)



Product Description:

Novel FLT3 inhibitor, displaying potent inhibitory activity against the FLT3-ITD mutant (IC50 = 0.8 nM) and good selectivity over c-KIT kinase (over 500-fold), selectively inhibiting the proliferation of FLT3-ITD-positive AML cell lines MV4-11 (IC50 = 23.5 nM) and MOLM-13 (IC50 = 35.5 nM) and exhibiting potent inhibitory effects against associated acquired resistance mutations




Analytical data click for PDF file



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