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CAS: N/A
Chemical Name: IRAK3 degrader D-1; (2S,4R)-1-((S)-2-((1r,4S)-4-(4-(4-(6-Amino-5-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-3-yl)-1H-pyrazol-1-yl)piperidine-1-carbonyl)cyclohexane-1-carboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide
Purity: >98% (HPLC)
Novel selective proteasomal degrader of IRAK3, reproducing the 1L-12p40 increases observed in the CRISPR/Cas9 knockout
Ref: https://pubs.acs.org/doi/10.1021/acschembio.2c00037
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