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Glixx Laboratorie
CAS: 2645409-78-3
Chemical Name: 2-((2-Acrylamido-4-(4-methylpiperazin-1-yl)phenyl)amino)-N-(2,6-diethylphenyl)-5,6-dihydropyrimido[4,5-e]indolizine-7-carboxamide
Purity: >98% (HPLC)
The first irreversible covalent MPS1 inhibitor, targeting a poorly conserved cysteine in the kinase's hinge region
Ref: https://pubs.acs.org/doi/10.1021/acs.jmedchem.1c01165
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