Glixx Laboratories Inc
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Glixx Laboratorie
CAS: 2376257-44-0
Chemical Name: PLN-74809; (2S)-4-[2-Methoxyethyl-[4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)butyl]amino]-2-(quinazolin-4-ylamino)butanoic acid
Purity: >98% (HPLC)
Novel dual αvβ6/αvβ1 integrin inhibitor, dose-dependently inhibiting pulmonary Smad3 phosphorylation and collagen deposition, more potently reducing collagen gene expression in fibrotic human and mouse lung slices than clinically relevant concentrations of nintedanib or pirfenidone
Reference:
https://respiratory-research.biomedcentral.com/articles/10.1186/s12931-021-01863-0
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