Glixx Laboratories Inc

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DSM421

 

CAS: 2011769-21-2

 

Chemical Name: 2-(1,1-Difluoroethyl)-5-methyl-N-(6-(trifluoromethyl)pyridin-3-yl)[1,2,4]triazolo[1,5-a]pyrimidin-7-amine

 

 
GLXC-24130For Lab R&D Uses Only
        Cat No: GLXC-24130

 

Purity:               >98% (HPLC)

Storage:             Refrigerator (4 °C)

 

 

Product Description:

Novel potent and selecrive PfDHODH inhibitor which has improved solubility, lower intrinsic clearance, and increased plasma exposure after oral dosing compared to DSM265, while maintaining a long predicted human half-life. Its improved physical and chemical properties will allow it to be formulated more readily than DSM265

 

References:

1) https://onlinelibrary.wiley.com/doi/abs/10.1002/cbdv.201900365

2) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6803055/

3) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5148661/

 

Analytical data click for PDF file

 

 

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