For Lab R&D Uses Only

Purity:               >98% (HPLC)

Product Description:

Novel high-affinity fluorescent probe for the detection of soluble and insoluble Aβ deposits in Alzheimer’s disease, showing an admirable fluorescence emission (>600 nm) change after binding with soluble Aβ oligomers (2.3-fold) and insoluble Aβ fibril aggregates (4.5-fold) with  high affinities Kd = 24.25 ± 4.10 nM; Ka = (4.123 ± 0.69) × 107 M-1 for fibrils; Kd = 32.58 ± 4.89 nM; and Ka = (3.069 ± 0.46) × 107 M-1 for oligomers with high quantum yield, molecular weight of <500 Da, reasonable log P = 1.77, stability in serum, and nontoxicity, and being able to cross the BBB efficientlyNatural ceramide, improving learning and short-term memory behavior, increasing calcium influx, CaMKII/CREB, and the Erk-relevant signaling transduction

Reference:

https://pubs.acs.org/doi/10.1021/acschemneuro.2c00787

Analytical data

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