Glixx Laboratories Inc

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Glixx Laboratorie

 

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AM-8621

 

CAS: N/A

 

Chemical Name: (3'R,4S,6'R,7'S,8'E,12'R)-7-Chloro-12'-ethyl-7'-hydroxy-13',13'-dioxospiro[2,3-dihydro-1H-naphthalene-4,22'-20-oxa-13λ6-thia-1,14-diazatetracyclo[14.7.2.03,6.019,24]pentacosa-8,16(25),17,19(24)-tetraene]-15'-one

 

 
GLXC-27322For Lab R&D Uses Only
        Cat No: GLXC-27322

 

Purity:               >98% (HPLC)

Storage:             Refrigerator (4 °C)

 

 

Product Description:

Novel potent MCL1 inhibitor, disrupting the interaction between MCL1 and proapoptotic BCL2 family members and also inducing MCL1 protein levels, exhibiting picomolar affinity for human MCL1, approximately 1,000-fold reduced affinity toward murine MCL1, and minimal binding affinity toward BCL2 and BCL-xL

 

Reference:

https://aacrjournals.org/cancerdiscovery/article/8/12/1582/190903/AMG-176-a-Selective-MCL1-Inhibitor-Is-Effective-in


 

Analytical data click for PDF file

 

 

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