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CAS: N/A
Chemical Name: (3'R,4S,6'R,7'S,8'E,12'R)-7-Chloro-12'-ethyl-7'-hydroxy-13',13'-dioxospiro[2,3-dihydro-1H-naphthalene-4,22'-20-oxa-13λ6-thia-1,14-diazatetracyclo[14.7.2.03,6.019,24]pentacosa-8,16(25),17,19(24)-tetraene]-15'-one
Purity: >98% (HPLC)
Novel potent MCL1 inhibitor, disrupting the interaction between MCL1 and proapoptotic BCL2 family members and also inducing MCL1 protein levels, exhibiting picomolar affinity for human MCL1, approximately 1,000-fold reduced affinity toward murine MCL1, and minimal binding affinity toward BCL2 and BCL-xL
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