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CAS: N/A
Chemical Name: (3R,5S)-1-((S)-2-(2-(2-(2-(4-(5-((4-((3-Chloro-4-fluorophenyl)amino)-6-((E)-4-(piperidin-1-yl)but-2-enamido)quinazolin-7-yl)oxy)pentyl)-1H-1,2,3-triazol-1-yl)ethoxy)ethoxy)acetamido)-3,3-dimethylbutanoyl)-5-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-3-yl ((1-methyl-2-nitro-1H-imidazol-5-yl)methyl) carbonate
Purity: >98% (HPLC)
The first NTR-responsive PROTAC, incorporating the caging group on the Von Hippel-Lindau (VHL) E3 ubiquitin ligase ligand, efficiently degrading the EGFR protein and subsequently exert antitumor efficacy
Ref: https://pubs.acs.org/doi/10.1021/acs.jmedchem.1c02221
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