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Antileishmanial agent 4

 

CAS: N/A

 

Chemical Name: (4-Bromophenyl)(1-(4-bromophenyl)-1H-1,2,3-triazol-4-yl)methanol

 

 
For Lab R&D Uses Only
        Cat No: GLXC-24422

 

Purity:               >98% (HPLC)

Storage:             Refrigerator (4 °C)

 

 

Product Description:

Novel antileishmanial agent against L. amazonensis promastigotes (IC50 = 15.52 ± 3.782 μM) and intracellular amastigotes (IC50 = 4.10 ± 1.136 μM), 50% cytotoxicity concentration at 84.01 ± 3.064 μM against BALB/c peritoneal macrophages, and 20.49-fold selectivity for the parasite over the cells, inducing ultrastructural mitochondrial alterations and lipid inclusions in L. amazonensis promastigotes, upregulating tumor necrosis factor α, interleukin (IL)-1β, IL-6, IL-12, and IL-10 messenger RNA expressions, and enhancing the NO production

 

Ref: https://pubs.acs.org/doi/10.1021/acs.jmedchem.1c00725

 

Analytical data click for PDF file

 

 

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