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CAS: 2946593-60-6
Chemical Name: (4R)-4-(3-(7-(8-Ethynyl-7-fluoro-3-hydroxynaphthalen-1-yl)-8-fluoro-2-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)pyrido[4,3-d]pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octane-8-carbonyl)-3,3-dimethyloxetan-2-one
For Lab R&D Uses Only
Purity: >98% (HPLC)
Novel highly mutant-selective covalent ligand for KRAS-G12, completely labeling K-Ras-G12D-GDP and K-Ras-G12D-GppNHp within 30 min and 300 min, respectively
Reference:
https://www.nature.com/articles/s41589-024-01565-w
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