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CAS: N/A
Chemical Name: Methyl (E)-3-[3-[[3-cyano-4-[4-(dimethylamino)phenyl]phenyl]methyl-(cyclohexanecarbonyl)amino]-5-fluorophenyl]prop-2-enoate
Purity: >98% (HPLC)
Novel intestine-specific FXR partial agonist, strongly inducing multiple intestinal FXR target genes, FGF15, SHP, IBABP, and OST-α, but failing to activate SHP in the liver, significantly reducing the liver fibrogenesis area, hepatic fibrosis markers, and serum level of AST
Reference:
https://pubs.acs.org/doi/10.1021/acs.jmedchem.2c00641
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