Glixx Laboratories Inc
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Glixx Laboratorie
CAS: N/A
Chemical Name: (1aS,3aS,4S,6aS,6bS,7R,9aR)-4-(((2,6-Dichlorophenyl)sulfonyl)methyl)-7-hydroxy-1a,7-dimethyloctahydro-3H-oxireno[2',3':8,8a]azuleno[4,5-b]furan-5(4H)-one
Purity: >98% (HPLC)
Novel ACT001 analog, exhibiting stronger inhibition of PD-L1 expression, less cytotoxicity to neutrophils, and lower BBB permeability than ACT001, significantly enhancing neutrophil-mediated antifungal immunity in C. albicans infected mice, with acceptable pharmacokinetic properties and good oral safety
Reference:
https://pubs.acs.org/doi/10.1021/acs.jmedchem.3c02453
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