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CAS: N/A
Chemical Name: (2S,4R)-1-((S)-2-(8-(4-(4-(2-Hexylhydrazine-1-carbonyl)phenyl)piperazin-1-yl)octanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide
Purity: >98% (HPLC)
Novel highly potent and selective HDAC8 proteolysis targeting chimera (PROTAC) degrader, exhibiting promising on-target antiproliferative activity against DLBCL cells with higher potency than the HDAC8 selective inhibitor PCI-34051
Reference:
https://pubs.acs.org/doi/10.1021/acs.jmedchem.4c00761
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