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CAS: N/A
Chemical Name: 1-(3-((4-Amino-1-(tert-butyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)oxy)azetidin-1-yl)prop-2-en-1-one
Purity: >98% (HPLC)
Novel covalent kinase probe, exhibiting a flipped binding mode where the C3 position is oriented toward the ribose binding pocket, forming a covalent bond with multiple kinases that possess a cysteine at the αD-1 position including BTK, EGFR, BLK, and JAK3
Reference:
https://pubs.acs.org/doi/10.1021/acs.jmedchem.3c01891
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