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CAS: N/A
Chemical Name: (2S,4R)-1-((S)-2-(6-(2-(4-(7-(1,1-Dioxido-4-oxo-1,2,5-thiadiazolidin-2-yl)-8-fluoro-6-hydroxynaphthalen-2-yl)-1H-pyrazol-1-yl)acetamido)hexanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide
Purity: >98% (HPLC)
Novel subtype-selective and efficient PTPN2 degrader (PTPN2/PTP1B selective index > 60-fold), inducing PTPN2 degradation in a ubiquitination- and proteasome-dependent manner
Reference:
https://pubs.acs.org/doi/10.1021/acs.jmedchem.3c01348
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