Glixx Laboratories Inc
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Glixx Laboratorie
CAS: 2924063-98-7
Chemical Name: (E)-3-(2,2-Difluorobenzo[d][1,3]dioxol-5-yl)-1-(4-(2-methoxypyrimidine-5-carbonyl)piperazin-1-yl)prop-2-en-1-one
Purity: >98% (HPLC)
First-in-class highly potent GPR183 antagonist for the potential treatment of rheumatoid arthritis, significantly reducing the swelling of paws and joints, the gene expression of proinflammatory cytokines, MCP-1, MMPs, and VEGF, inflammatory cell infiltration, cartilage damage, pannus formation, and bone erosion in the joints of CIA mice in a dose-dependent manner
Reference:
https://pubs.acs.org/doi/10.1021/acs.jmedchem.3c01364
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