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GPR183 antagonist 32


CAS: 2924063-98-7


Chemical Name: (E)-3-(2,2-Difluorobenzo[d][1,3]dioxol-5-yl)-1-(4-(2-methoxypyrimidine-5-carbonyl)piperazin-1-yl)prop-2-en-1-one


GLXC-28009For Lab R&D Uses Only
        Cat No: GLXC-28009


Purity:               >98% (HPLC)

Storage:             Refrigerator (4 °C)



Product Description:

First-in-class highly potent GPR183 antagonist for the potential treatment of rheumatoid arthritis, significantly reducing the swelling of paws and joints, the gene expression of proinflammatory cytokines, MCP-1, MMPs, and VEGF, inflammatory cell infiltration, cartilage damage, pannus formation, and bone erosion in the joints of CIA mice in a dose-dependent manner




Analytical data click for PDF file



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