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EGFR mutant degrader C6

 

CAS: N/A

 

Chemical Name: N-(2-(2,6-Dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)-7-(4-(4-((4-(1-(ethylsulfonyl)-1H-indol-3-yl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperazin-1-yl)heptanamide

 

 
GLXC-28251For Lab R&D Uses Only
        Cat No: GLXC-28251

 

Purity:               >98% (HPLC)

Storage:             Refrigerator (4 °C)

 

 

Product Description:

Novel EGFR PROTAC, exhibiting a DC50 of 10.2 nM against EGFRL858R/T790M/C797S and an IC50 of 10.3 nM against H1975-TM, showing potent degradation activity against various main EGFR mutants, including EGFRDel19/T790M/C797S, inhibiting tumor growth in the H1975-TM xenograft tumor model

 

Reference:

https://pubs.acs.org/doi/10.1021/acs.jmedchem.4c00107

 

Analytical data click for PDF file

 

 

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