Glixx Laboratories Inc
Your exclusive source for bioactive molecules
Glixx Laboratorie
CAS: N/A
Chemical Name: N-(2-(2,6-Dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)-7-(4-(4-((4-(1-(ethylsulfonyl)-1H-indol-3-yl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperazin-1-yl)heptanamide
Purity: >98% (HPLC)
Novel EGFR PROTAC, exhibiting a DC50 of 10.2 nM against EGFRL858R/T790M/C797S and an IC50 of 10.3 nM against H1975-TM, showing potent degradation activity against various main EGFR mutants, including EGFRDel19/T790M/C797S, inhibiting tumor growth in the H1975-TM xenograft tumor model
Reference:
https://pubs.acs.org/doi/10.1021/acs.jmedchem.4c00107
Place an order!
POA | |||
Bulk inquiry contact: | |||
sales@glixxlabs.com |
|||
service@glixxlabs.com |