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CAS: N/A
Chemical Name: 2-(3,5-Bis((E)-2-bromobenzylidene)-4-oxopiperidin-1-yl)-N-(2-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)ethoxy)ethyl)acetamide
Purity: >98% (HPLC)
The first potent DYRK2 proteolysis targeting chimera degrader, effectively downregulating the intracellular DYRK2 level (DC50 = 1.607 μM), inducing DYRK2 degradation through the ubiquitin-proteasome system
Reference:
https://pubs.acs.org/doi/10.1021/acsmedchemlett.4c00065
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