Glixx Laboratories Inc
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Glixx Laboratorie
CAS: 2738583-25-8
Chemical Name: (4-((3-Methyl-4-oxo-3,4-dihydrophthalazin-1-yl)methyl)phenyl)sulfamide; 2-Methyl-1-oxo-4-[[4-(sulfamoylamino)phenyl]methyl]phthalazine
Purity: >98% (HPLC)
Novel orally bioavailable ENPP1 inhibitor for STING-mediated cancer immunotherapy, inhibiting the cGAMP hydrolysis by ENPP1 in vitro (IC50 = 68 nM) and enhancing the STING-mediated type I interferon response in both immune and tumor cells, promoting tumor growth inhibition in a CT26 syngeneic model and increasing the anti-PD-L1 response
Reference:
https://pubs.acs.org/doi/10.1021/acs.jmedchem.3c01061
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