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CAS: N/A
Chemical Name: AZ’9567; 3-Cyclopropyl-4-(4-(difluoromethoxy)phenyl)-6-(2-methyl-2H-indazol-5-yl)-1,4-dihydro-5H-pyrazolo[4,3-b]pyridin-5-one
Purity: >98% (HPLC)
Novel in vivo MAT2a tool inhibitor, showing a selective antiproliferative effect on methylthioadenosine phosphorylase (MTAP) KO cells, both in vitro and in vivo, providing further evidence to support the utility of MAT2a inhibitors as potential anticancer therapies for MTAP-deficient tumors
Reference:
https://pubs.acs.org/doi/10.1021/acs.jmedchem.3c01860
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