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CAS: 2765082-12-8
Chemical Name: (1R,5S)-N-[(7S,13S)-20-[5-(4-Cyclopropylpiperazin-1-yl)-2-[(1S)-1-methoxyethyl]pyridin-3-yl]-21-ethyl-17,17-dimethyl-8,14-dioxo-15-oxa-4-thia-9,21,27,28-tetrazapentacyclo[17.5.2.12,5.19,13.022,26]octacosa-1(25),2,5(28),19,22(26),23-hexaen-7-yl]-3-oxabicyclo[3.1.0]hexane-6-carboxamide
Purity: >98% (HPLC)
Novel RAS(ON) multi-selective tri-complex inhibitor, demonstrating potent activity against RAS-addicted tumours carrying various RAS genotypes, particularly against cancer models with KRAS codon 12 mutations (KRASG12X)
References:
https://pubmed.ncbi.nlm.nih.gov/?term=RMC-7977&sort=date
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