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Glixx Laboratorie
CAS: N/A
Chemical Name: Methyl (E)-3-(3-(3-(3-hydroxyphenyl)prop-2-yn-1-yl)-1,7-dimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)acrylate
Purity: >98% (HPLC)
Novel mixed-lineage kinase domain-like (MLKL) inhibitor, demonstrating potent necroptosis inhibition and antifibrotic effects, inhibiting immune cell death, reducing the expression of adhesion molecules and the level of activation of hepatic stellate cells and the expression of hepatic fibrosis markers induced by necroptosis stimulation
Reference:
https://pubs.acs.org/doi/10.1021/acsptsci.3c00131
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