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Glixx Laboratorie
CAS: 1226443-41-9
Chemical Name: 2-[2-[(6-Methylpyridin-2-yl)amino]-1,3-thiazol-4-yl]-N-(5-methyl-1,3-thiazol-2-yl)acetamide
Purity: >98% (HPLC)
Novel molecular glue cyclin K degrader, acting by promoting an interaction between CDK12 and DDB1-CUL4-RBX1 E3 ubiquitin ligase, leading to polyubiquitination and degradation of CDK12-interacting protein Cyclin K (CCNK)
Reference:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7462607/
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