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Glixx Laboratorie
CAS: 2639957-39-2
Chemical Name: KIN-2787; (S)-N-(3-(2-(((R)-1-Hydroxypropan-2-yl)amino)-6-morpholinopyridin-4-yl)-4-methylphenyl)-3-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide
Purity: >98% (HPLC)
Novel highly potent and selective inhibitor of RAF kinase, intercepting the RAF protein in the dimer compatible αC-helix-IN conformation and demonstrating anti-tumor efficacy in preclinical models with BRAF class I, II, and III and NRAS alterations
Reference:
https://pubs.acs.org/doi/10.1021/acs.jmedchem.3c01830
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