Glixx Laboratories Inc
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Glixx Laboratorie
CAS: 2737262-24-5
Chemical Name: 14,25-Difluoro-N-(2-morpholinoethyl)-5,12-dioxa-3-aza-2(4,2)-pyrimidina-1,4(1,3)-dibenzenacyclododecaphane-44-carboxamide
Purity: >98% (HPLC)
Novel potent and selective CDK9 inhibitor (IC50 = 3.20 nM), significantly inhibiting cell proliferation and colony formation and induces apoptosis in Osimertinib-resistant H1975 cells, demonstrating a significant suppression of tumor growth in six patient-derived organoids, including three organoids resistant to Osimertinib (GLXC-05459)
Reference:
https://pubs.acs.org/doi/10.1021/acs.jmedchem.3c01400
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