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CAS: N/A
Chemical Name: (2S,4R)-1-((S)-2-(10-(4-(6-(1-(6-Amino-5-((2,3-dichlorophenyl)thio)pyrazin-2-yl)-4-(aminomethyl)piperidin-4-yl)hexanoyl)piperazin-1-yl)decanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide
Purity: >98% (HPLC)
Novel allosteric SHP2 degrader (DC50 = 35.2 ± 1.5 nM) with in vivo anti-tumor activity
Reference:
https://www.mdpi.com/1420-3049/28/19/6947
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