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CAS: N/A
Chemical Name: (R)-1-((3S,6S,9S,18S)-9-(Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-N6-(6-aminohexanoyl)amido-18-carbamoyl-2,5,8,12-tetraoxo-6-((1-(8-phenyloctyl)-1H-imidazol-5-yl)methyl)-1,4,7,13-tetraazacyclooctadecan-3-yl)ethyl dihydrogen phosphate
Purity: >98% (HPLC)
Novel polo-like kinase 1 (PLK1) degrader, selectively inducing PLK1 degradation in cancer cells, including HeLa and nonsmall cell lung cancer (NSCLC), through the N-degron pathway
Reference:
https://pubs.acs.org/doi/10.1021/acs.jmedchem.3c01493
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