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Triptolide prodrug CX-23

 

CAS: N/A

 

Chemical Name: (5bS,6aS,7aR,8R,8aS,9aS,9bS,10aS,10bS)-8a-Isopropyl-10b-methyl-3-oxo-1,2,3,5,5b,6,6a,8,8a,9a,9b,10b-dodecahydrotris(oxireno)[2',3':4b,5;2'',3'':6,7;2''',3''':8a,9]phenanthro[1,2-c]furan-8-yl 3-methyl-3-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dien-1-yl)butanoate

 

 
GLXC-27765For Lab R&D Uses Only
        Cat No: GLXC-27765

 

Purity:               >98% (HPLC)

Storage:             Refrigerator (4 °C)

 

 

Product Description:

Novel selective NAD(P)H:quinone oxidoreductase 1 (NQO1) activated prodrug of triptolide, blocking AKT phosphorylation, leading to reduced expression of Mcl-1 and Bcl-2, and upregulating cleaved-caspase-3 levels, ultimately inducing apoptosis in cancer cells

 

References:

https://pubs.acs.org/doi/10.1021/acsptsci.3c00144

https://pubs.acs.org/doi/abs/10.1021/acsmedchemlett.8b00404

 

Analytical data click for PDF file

 

 

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