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CAS: N/A
Chemical Name: (S)-1-((R)-6-Isopropyl-3-(4-(1,2,3,4-tetrahydroquinoline-1-carbonyl)phenyl)-6,7-dihydropyrazolo[1,5-a]pyrazin-5(4H)-yl)-2-methoxy-2-(1-methyl-1H-pyrazol-4-yl)ethan-1-one
For Lab R&D Uses Only
Purity: >98% (HPLC)
Novel parkin activator, acting as a molecular glue to enhance the ability of phospho-ubiquitin (pUb) to activate parkin, partially rescuing the activity of parkin EOPD mutants, R42P and V56E
References:
https://www.nature.com/articles/s41467-024-51889-3
https://www.cell.com/iscience/fulltext/S2589-0042(21)01620-5
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