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Glixx Laboratorie
CAS: N/A
Chemical Name: HPK1-IN-49; (S)-5-((4-((1-(4-Fluorophenyl)-2-hydroxyethyl-2,2-d2)amino)-5-(1,3,4-oxadiazol-2-yl)pyrimidin-2-yl)amino)-3,3-dimethylisoindolin-1-one
Purity: >98% (HPLC)
Novel highly potent HPK1 inhibitor (IC50 = 0.9 nM), effectively inhibiting pSLP76 and reinvigorating T-cell receptor (TCR) signaling, promoting T-cell function and cytokine production both in naïve and antigen-specific T cells, enhancing the antitumor efficacy of anti-PD1 at a well-tolerant dosage
Reference:
https://pubs.acs.org/doi/abs/10.1021/acs.jmedchem.3c01571
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