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HPK1 inhibitor 49

 

CAS: N/A

 

Chemical Name: HPK1-IN-49; (S)-5-((4-((1-(4-Fluorophenyl)-2-hydroxyethyl-2,2-d2)amino)-5-(1,3,4-oxadiazol-2-yl)pyrimidin-2-yl)amino)-3,3-dimethylisoindolin-1-one

 

 
GLXC-27984For Lab R&D Uses Only
        Cat No: GLXC-27984

 

Purity:               >98% (HPLC)

Storage:             Refrigerator (4 °C)

 

 

Product Description:

Novel highly potent HPK1 inhibitor (IC50 = 0.9 nM), effectively inhibiting pSLP76 and reinvigorating T-cell receptor (TCR) signaling, promoting T-cell function and cytokine production both in naïve and antigen-specific T cells, enhancing the antitumor efficacy of anti-PD1 at a well-tolerant dosage

 

Reference:

https://pubs.acs.org/doi/abs/10.1021/acs.jmedchem.3c01571

 

Analytical data click for PDF file

 

 

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