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CAS: N/A
Chemical Name: N-(3-Chloro-2-fluorophenyl)-6-(4-((2,6-dimethoxy-4-((2-methyl-[1,1'-biphenyl]-3-yl)methoxy)benzyl)amino)butoxy)-7-methoxyquinazolin-4-amine
Purity: >98% (HPLC)
Novel dual inhibitor of EGFR and PD-L1 (EGFR IC50 = 37.5 nM and PD-1/PD-L1 interaction IC50 = 1.77 μM), displaying superior in vitro antiproliferative activities and in vitro immunomodulatory effects by promoting U87MG cell death in a U87MG/Jurkat cell coculture model, increasing CD4+ cells and CD8+ cells in tumor microenvironment
Reference:
https://pubs.acs.org/doi/10.1021/acs.jmedchem.4c00128
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