Glixx Laboratories Inc

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Glixx Laboratorie

 

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EP26

 

CAS: N/A

 

Chemical Name: N-(3-Chloro-2-fluorophenyl)-6-(4-((2,6-dimethoxy-4-((2-methyl-[1,1'-biphenyl]-3-yl)methoxy)benzyl)amino)butoxy)-7-methoxyquinazolin-4-amine

 

 
GLXC-28551For Lab R&D Uses Only
        Cat No: GLXC-28551

 

Purity:               >98% (HPLC)

Storage:             Refrigerator (4 °C)

 

 

Product Description:

Novel dual inhibitor of EGFR and PD-L1 (EGFR IC50 = 37.5 nM and PD-1/PD-L1 interaction IC50 = 1.77 μM), displaying superior in vitro antiproliferative activities and in vitro immunomodulatory effects by promoting U87MG cell death in a U87MG/Jurkat cell coculture model, increasing CD4+ cells and CD8+ cells in tumor microenvironment

 

Reference:

https://pubs.acs.org/doi/10.1021/acs.jmedchem.4c00128


Analytical data click for PDF file

 

 

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